Two sample MR report
RPS26_Monocyte (Mono) against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 8 | -0.0125031 | 0.0528195 | 0.8207535 |
| Weighted median | 8 | -0.0548966 | 0.0114711 | 0.0000017 |
| Inverse variance weighted | 8 | -0.0546526 | 0.0090743 | 0.0000000 |
| Simple mode | 8 | -0.0457516 | 0.0175097 | 0.0347645 |
| Weighted mode | 8 | -0.0514307 | 0.0169054 | 0.0187867 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 2.433656 | 6 | 0.8758175 |
| Inverse variance weighted | 3.089812 | 7 | 0.8765714 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0200845 | 0.0247947 | 0.4488458 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0005217 | 0 | TRUE | 0.0309227 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
